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==Structure of murine cytosolic 5'-nucleotidase III complexed with thymidine monophosphate==
==Structure of murine cytosolic 5'-nucleotidase III complexed with thymidine monophosphate==
<StructureSection load='4kx3' size='340' side='right' caption='[[4kx3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4kx3' size='340' side='right'caption='[[4kx3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KX3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kx3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KX3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fe3|4fe3]], [[2g06|2g06]], [[2g09|2g09]], [[4kx5|4kx5]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nt5c3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx3 OCA], [https://pdbe.org/4kx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kx3 RCSB], [https://www.ebi.ac.uk/pdbsum/4kx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kx3 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kx3 RCSB], [http://www.ebi.ac.uk/pdbsum/4kx3 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/5NT3A_MOUSE 5NT3A_MOUSE] Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.[UniProtKB:Q9H0P0]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 5'-nucleotidase]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Bingman, C A]]
[[Category: Bingman CA]]
[[Category: Bitto, E]]
[[Category: Bitto E]]
[[Category: Grobosky, C L]]
[[Category: Grobosky CL]]
[[Category: Cytosolic 5'-nucleotidase iii]]
[[Category: Had superfamily]]
[[Category: Hydrolase]]
[[Category: Nucleotidase]]
[[Category: P5n-1]]
[[Category: Substrate complex]]
[[Category: Umph-1]]

Latest revision as of 06:31, 12 February 2025

Structure of murine cytosolic 5'-nucleotidase III complexed with thymidine monophosphate

4kx3, resolution 2.10Å

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