4l9k: Difference between revisions

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==X-ray study of human serum albumin complexed with camptothecin==
==X-ray study of human serum albumin complexed with camptothecin==
<StructureSection load='4l9k' size='340' side='right' caption='[[4l9k]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4l9k' size='340' side='right'caption='[[4l9k]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L9K FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EHF:(2S)-2-HYDROXY-2-[8-(HYDROXYMETHYL)-9-OXO-9,11-DIHYDROINDOLIZINO[1,2-B]QUINOLIN-7-YL]BUTANOIC+ACID'>EHF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l8u|4l8u]], [[4l9q|4l9q]], [[4la0|4la0]], [[4lb2|4lb2]], [[4lb9|4lb9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EHF:(2S)-2-HYDROXY-2-[8-(HYDROXYMETHYL)-9-OXO-9,11-DIHYDROINDOLIZINO[1,2-B]QUINOLIN-7-YL]BUTANOIC+ACID'>EHF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l9k RCSB], [http://www.ebi.ac.uk/pdbsum/4l9k PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9k OCA], [https://pdbe.org/4l9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9k RCSB], [https://www.ebi.ac.uk/pdbsum/4l9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9k ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4l9k" style="background-color:#fffaf0;"></div>
==See Also==
*[[Albumin 3D structures|Albumin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Carter, D C]]
[[Category: Large Structures]]
[[Category: Ho, J X]]
[[Category: Carter DC]]
[[Category: Rose, J P]]
[[Category: Ho JX]]
[[Category: Ruble, J]]
[[Category: Rose JP]]
[[Category: Wang, Z]]
[[Category: Ruble J]]
[[Category: Cancer]]
[[Category: Wang Z]]
[[Category: Oncology drug complex]]
[[Category: Plasma protein]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4l9k"