2c2h: Difference between revisions
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New page: left|200px<br /> <applet load="2c2h" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c2h, resolution 1.85Å" /> '''CRYSTAL STRUCTURE O... |
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== | ==CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP== | ||
<StructureSection load='2c2h' size='340' side='right'caption='[[2c2h]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2c2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2h OCA], [https://pdbe.org/2c2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2h RCSB], [https://www.ebi.ac.uk/pdbsum/2c2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2h ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2h_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c2h ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Rac 3D structures|Rac 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Bunkoczi | [[Category: Bunkoczi G]] | ||
[[Category: Burgess | [[Category: Burgess N]] | ||
[[Category: Colebrook | [[Category: Colebrook S]] | ||
[[Category: Debreczeni | [[Category: Debreczeni JE]] | ||
[[Category: Doyle D]] | |||
[[Category: Doyle | [[Category: Edwards A]] | ||
[[Category: Edwards | [[Category: Elkins J]] | ||
[[Category: Elkins | [[Category: Fedorov O]] | ||
[[Category: Fedorov | [[Category: Gileadi C]] | ||
[[Category: Gileadi | [[Category: Gileadi O]] | ||
[[Category: Gileadi | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Yang X]] | ||
[[Category: Yang | [[Category: Zao Y]] | ||
[[Category: Zao | [[Category: Von Delft F]] | ||
[[Category: | |||
Latest revision as of 14:03, 13 December 2023
CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP
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