4hi8: Difference between revisions
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==Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800== | ==Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800== | ||
<StructureSection load='4hi8' size='340' side='right' caption='[[4hi8]], [[Resolution|resolution]] 1.20Å' scene=''> | <StructureSection load='4hi8' size='340' side='right'caption='[[4hi8]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4hi8]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4hi8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HI8 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.203Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hi8 OCA], [https://pdbe.org/4hi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hi8 RCSB], [https://www.ebi.ac.uk/pdbsum/4hi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hi8 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Boggon | [[Category: Boggon TJ]] | ||
[[Category: Calderwood | [[Category: Calderwood DA]] | ||
[[Category: Chiswell | [[Category: Chiswell BP]] | ||
[[Category: Jakoncic | [[Category: Jakoncic J]] | ||
[[Category: Stiegler | [[Category: Stiegler AL]] | ||
[[Category: Stojanoff | [[Category: Stojanoff V]] | ||
Latest revision as of 15:06, 20 September 2023
Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
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