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[[Image:1sum.gif|left|200px]]


{{Structure
==Crystal structure of a hypothetical protein at 2.0 A resolution==
|PDB= 1sum |SIZE=350|CAPTION= <scene name='initialview01'>1sum</scene>, resolution 2.00&Aring;
<StructureSection load='1sum' size='340' side='right'caption='[[1sum]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=PO3:PHOSPHITE ION'>PO3</scene>
<table><tr><td colspan='2'>[[1sum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SUM FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO3:PHOSPHITE+ION'>PO3</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sum OCA], [https://pdbe.org/1sum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sum RCSB], [https://www.ebi.ac.uk/pdbsum/1sum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sum ProSAT], [https://www.topsan.org/Proteins/BSGC/1sum TOPSAN]</span></td></tr>
 
</table>
'''Crystal structure of a hypothetical protein at 2.0 A resolution'''
== Function ==
 
[https://www.uniprot.org/uniprot/PHOU2_THEMA PHOU2_THEMA] Plays a role in the regulation of phosphate uptake (By similarity).
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
PhoU proteins are known to play a role in the regulation of phosphate uptake. In Thermotoga maritima, two PhoU homologues have been identified bioinformatically. Here we report the crystal structure of one of the PhoU homologues at 2.0 A resolution. The structure of the PhoU protein homologue contains a highly symmetric new structural fold composed of two repeats of a three-helix bundle. The structure unexpectedly revealed a trinuclear and a tetranuclear iron cluster that were found to be bound on the surface. Each of the two multinuclear iron clusters is coordinated by a conserved E(D)XXXD motif pair. Our structure reveals a new class of metalloprotein containing multinuclear iron clusters. The possible functional implication based on the structure are discussed.
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1sum_consurf.spt"</scriptWhenChecked>
1SUM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUM OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters., Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH, J Biol Chem. 2005 Apr 22;280(16):15960-6. Epub 2005 Feb 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15716271 15716271]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sum ConSurf].
[[Category: Single protein]]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Adams, P D.]]
[[Category: Adams PD]]
[[Category: BSGC, Berkeley Structural Genomics Center.]]
[[Category: Kim R]]
[[Category: Kim, R.]]
[[Category: Kim SH]]
[[Category: Kim, S H.]]
[[Category: Liu J]]
[[Category: Liu, J.]]
[[Category: Lou Y]]
[[Category: Lou, Y.]]
[[Category: Yokota H]]
[[Category: Yokota, H.]]
[[Category: CA]]
[[Category: FE]]
[[Category: NI]]
[[Category: PO3]]
[[Category: abc transport]]
[[Category: berkeley structural genomics center]]
[[Category: bsgc]]
[[Category: phou]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: pst]]
[[Category: structural genomic]]
[[Category: structure funded by nih]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:09:49 2008''

Latest revision as of 08:35, 1 May 2024

Crystal structure of a hypothetical protein at 2.0 A resolution

1sum, resolution 2.00Å

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