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==The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor==
==The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor==
<StructureSection load='4k4o' size='340' side='right' caption='[[4k4o]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='4k4o' size='340' side='right'caption='[[4k4o]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4k4o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K4O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4k4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K4O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [https://pdbe.org/4k4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [https://www.ebi.ac.uk/pdbsum/4k4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k4o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [http://www.ebi.ac.uk/pdbsum/4k4o PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA]


==See Also==
==See Also==
*[[Gyrase|Gyrase]]
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Entfa]]
[[Category: Enterococcus faecalis V583]]
[[Category: Akers-Rodriguez, S]]
[[Category: Large Structures]]
[[Category: Bensen, D C]]
[[Category: Akers-Rodriguez S]]
[[Category: Lam, T]]
[[Category: Bensen DC]]
[[Category: Tari, L W]]
[[Category: Lam T]]
[[Category: Atp-binding]]
[[Category: Tari LW]]
[[Category: Atp-binding domain]]
[[Category: Cytosol]]
[[Category: Isomerase-isomerase inhibitor complex]]
[[Category: Nucleotide-binding]]
[[Category: Topoisomerase]]
Retrieved from "https://proteopedia.org/4k4o"