4kfz: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Crystal structure of LMO2 and anti-LMO2 VH complex==
==Crystal structure of LMO2 and anti-LMO2 VH complex==
<StructureSection load='4kfz' size='340' side='right' caption='[[4kfz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4kfz' size='340' side='right'caption='[[4kfz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kfz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KFZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kfz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KFZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LMO2, RBTN2, RBTNL1, RHOM2, TTG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Anti-LMO2 VH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [http://www.ebi.ac.uk/pdbsum/4kfz PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kfz OCA], [https://pdbe.org/4kfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kfz RCSB], [https://www.ebi.ac.uk/pdbsum/4kfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kfz ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.  
[https://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.  
[https://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 20:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4kfz" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Chambers, J]]
[[Category: Large Structures]]
[[Category: Cruz-Migoni, A]]
[[Category: Chambers J]]
[[Category: Fuentes-Fernandez, N]]
[[Category: Cruz-Migoni A]]
[[Category: Mancini, E J]]
[[Category: El Omari K]]
[[Category: Omari, K El]]
[[Category: Fuentes-Fernandez N]]
[[Category: Rabbitts, T H]]
[[Category: Mancini EJ]]
[[Category: Sewell, H]]
[[Category: Rabbitts TH]]
[[Category: Tanaka, T]]
[[Category: Sewell H]]
[[Category: Developmental protein]]
[[Category: Tanaka T]]
[[Category: Lim domain]]
[[Category: Nucleus]]
[[Category: Oncoprotein]]
[[Category: Proto-oncogene]]
[[Category: T-cell leukemia]]
[[Category: Transcription]]
[[Category: Transcription factor]]
Retrieved from "https://proteopedia.org/4kfz"