1tge: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1tge.gif|left|200px]]


{{Structure
==The structure of immature Dengue virus at 12.5 angstrom==
|PDB= 1tge |SIZE=350|CAPTION= <scene name='initialview01'>1tge</scene>
<SX load='1tge' size='340' side='right' viewer='molstar' caption='[[1tge]], [[Resolution|resolution]] 12.50&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1tge]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2_Puerto_Rico/PR159-S1/1969 Dengue virus 2 Puerto Rico/PR159-S1/1969]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TGE FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12.5&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tge OCA], [https://pdbe.org/1tge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tge RCSB], [https://www.ebi.ac.uk/pdbsum/1tge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tge ProSAT]</span></td></tr>
}}
</table>
 
== Function ==
'''The structure of immature Dengue virus at 12.5 angstrom'''
[https://www.uniprot.org/uniprot/POLG_DEN2T POLG_DEN2T] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).  Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).  Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential).  Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity).  Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity).
 
__TOC__
 
</SX>
==Overview==
[[Category: Dengue virus 2 Puerto Rico/PR159-S1/1969]]
Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
[[Category: Large Structures]]
 
[[Category: Baker TS]]
==About this Structure==
[[Category: Clements D]]
1TGE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGE OCA].  
[[Category: Kuhn RJ]]
 
[[Category: Ogata S]]
==Reference==
[[Category: Rossmann MG]]
Conformational changes of the flavivirus E glycoprotein., Zhang Y, Zhang W, Ogata S, Clements D, Strauss JH, Baker TS, Kuhn RJ, Rossmann MG, Structure. 2004 Sep;12(9):1607-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341726 15341726]
[[Category: Strauss JH]]
[[Category: Dengue virus type 3]]
[[Category: Zhang W]]
[[Category: Single protein]]
[[Category: Zhang Y]]
[[Category: Baker, T S.]]
[[Category: Clements, D.]]
[[Category: Kuhn, R J.]]
[[Category: Ogata, S.]]
[[Category: Rossmann, M G.]]
[[Category: Strauss, J H.]]
[[Category: Zhang, W.]]
[[Category: Zhang, Y.]]
[[Category: dengue immature virus]]
[[Category: flavivirus]]
[[Category: icosahedral virus]]
[[Category: prm particle]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:18:04 2008''

Latest revision as of 08:39, 14 February 2024

The structure of immature Dengue virus at 12.5 angstrom

Loading...

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1tge&oldid=4055522"