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[[Image:1tmk.jpg|left|200px]]


{{Structure
==YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)==
|PDB= 1tmk |SIZE=350|CAPTION= <scene name='initialview01'>1tmk</scene>, resolution 2.1&Aring;
<StructureSection load='1tmk' size='340' side='right'caption='[[1tmk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=TMP:THYMIDINE-5'-PHOSPHATE'>TMP</scene>
<table><tr><td colspan='2'>[[1tmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TMK FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= CDC8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmk OCA], [https://pdbe.org/1tmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tmk RCSB], [https://www.ebi.ac.uk/pdbsum/1tmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KTHY_YEAST KTHY_YEAST] Catalyzes the conversion of dTMP to dTDP.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tmk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tmk ConSurf].
<div style="clear:both"></div>


'''YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)'''
==See Also==
 
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
==About this Structure==
__TOC__
1TMK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMK OCA].
</StructureSection>
 
[[Category: Large Structures]]
==Reference==
Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation., Lavie A, Vetter IR, Konrad M, Goody RS, Reinstein J, Schlichting I, Nat Struct Biol. 1997 Aug;4(8):601-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9253404 9253404]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Lavie A]]
[[Category: dTMP kinase]]
[[Category: Schlichting I]]
[[Category: Lavie, A.]]
[[Category: Schlichting, I.]]
[[Category: SO4]]
[[Category: TMP]]
[[Category: enzyme]]
[[Category: kinase]]
[[Category: thymidine activation pathway]]
[[Category: transferase (phosphotransferase)]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:20:24 2008''
Retrieved from "https://proteopedia.org/1tmk"