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[[Image:1tqj.gif|left|200px]]


{{Structure
==Crystal structure of D-ribulose 5-phosphate 3-epimerase from Synechocystis to 1.6 angstrom resolution==
|PDB= 1tqj |SIZE=350|CAPTION= <scene name='initialview01'>1tqj</scene>, resolution 1.60&Aring;
<StructureSection load='1tqj' size='340' side='right'caption='[[1tqj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1tqj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQJ FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Ribulose-phosphate_3-epimerase Ribulose-phosphate 3-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.1 5.1.3.1]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
|GENE= RPE, SLL0807 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1143 Synechocystis sp.])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqj OCA], [https://pdbe.org/1tqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqj RCSB], [https://www.ebi.ac.uk/pdbsum/1tqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqj ProSAT]</span></td></tr>
}}
</table>
 
== Function ==
'''Crystal structure of D-ribulose 5-phosphate 3-epimerase from Synechocystis to 1.6 angstrom resolution'''
[https://www.uniprot.org/uniprot/RPE_SYNY3 RPE_SYNY3] Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate (By similarity).
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The crystal structure of D-ribulose 5-phosphate 3-epimerase (RPE) from the cyanobacterium Synechocystis was determined by X-ray crystallography to 1.6 A resolution. The enzyme, which catalyzes the epimerization of D-ribulose 5-phosphate and D-xylulose 5-phosphate, assembles as a hexamer of (beta/alpha)(8)-barrels in the crystallographic asymmetric unit. The active site is highly similar to those of two previously reported RPEs and provides further evidence for essential catalytic roles for several active-site residues.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqj_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
1TQJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQJ OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqj ConSurf].
Structure of D-ribulose 5-phosphate 3-epimerase from Synechocystis to 1.6 A resolution., Wise EL, Akana J, Gerlt JA, Rayment I, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1687-90. Epub 2004, Aug 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15333955 15333955]
<div style="clear:both"></div>
[[Category: Ribulose-phosphate 3-epimerase]]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Synechocystis sp.]]
[[Category: Large Structures]]
[[Category: Akana, J.]]
[[Category: Synechocystis sp]]
[[Category: Gerlt, J A.]]
[[Category: Akana J]]
[[Category: Rayment, I.]]
[[Category: Gerlt JA]]
[[Category: Wise, E L.]]
[[Category: Rayment I]]
[[Category: beta-alpha barrel epimerase]]
[[Category: Wise EL]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:21:51 2008''

Latest revision as of 08:41, 14 February 2024

Crystal structure of D-ribulose 5-phosphate 3-epimerase from Synechocystis to 1.6 angstrom resolution

1tqj, resolution 1.60Å

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