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[[Image:1u3f.jpg|left|200px]]


{{Structure
==Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)==
|PDB= 1u3f |SIZE=350|CAPTION= <scene name='initialview01'>1u3f</scene>, resolution 2.50&Aring;
<StructureSection load='1u3f' size='340' side='right'caption='[[1u3f]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
<table><tr><td colspan='2'>[[1u3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3F FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/5-formyltetrahydrofolate_cyclo-ligase 5-formyltetrahydrofolate cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.2 6.3.3.2]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3f OCA], [https://pdbe.org/1u3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3f RCSB], [https://www.ebi.ac.uk/pdbsum/1u3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3f ProSAT], [https://www.topsan.org/Proteins/BSGC/1u3f TOPSAN]</span></td></tr>
 
</table>
'''Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)'''
== Function ==
 
[https://www.uniprot.org/uniprot/MTHFS_MYCPN MTHFS_MYCPN] Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.<ref>PMID:16104022</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1U3F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3F OCA].  
Check<jmol>
 
  <jmolCheckbox>
==Reference==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3f_consurf.spt"</scriptWhenChecked>
Crystal structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087) at 2.2 A resolution., Chen S, Shin DH, Pufan R, Kim R, Kim SH, Proteins. 2004 Sep 1;56(4):839-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15281135 15281135]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: 5-formyltetrahydrofolate cyclo-ligase]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3f ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Single protein]]
[[Category: Chen S]]
[[Category: BSGC, Berkeley Structural Genomics Center.]]
[[Category: Kim R]]
[[Category: Chen, S.]]
[[Category: Kim S-H]]
[[Category: Kim, R.]]
[[Category: Proudfoot M]]
[[Category: Kim, S H.]]
[[Category: Yakunin AF]]
[[Category: Proudfoot, M.]]
[[Category: Yakunin, A F.]]
[[Category: ADP]]
[[Category: MG]]
[[Category: PO4]]
[[Category: 5,10-methenyltetrahydrofolate synthetase]]
[[Category: atp binding]]
[[Category: berkeley structural genomics center]]
[[Category: bsgc structure funded by nih]]
[[Category: ligase]]
[[Category: mthf]]
[[Category: mycoplasma pneumoniae]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
 
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Retrieved from "https://proteopedia.org/1u3f"