1v4q: Difference between revisions

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[[Image:1v4q.gif|left|200px]]


{{Structure
==Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC==
|PDB= 1v4q |SIZE=350|CAPTION= <scene name='initialview01'>1v4q</scene>
<StructureSection load='1v4q' size='340' side='right'caption='[[1v4q]]' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
<table><tr><td colspan='2'>[[1v4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V4Q FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 18 models</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4q OCA], [https://pdbe.org/1v4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v4q RCSB], [https://www.ebi.ac.uk/pdbsum/1v4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v4q ProSAT]</span></td></tr>
 
</table>
'''Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC'''
== Function ==
 
[https://www.uniprot.org/uniprot/O17C_CONMA O17C_CONMA] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:10938268, PubMed:1352986). Shows also an inhibition on Cav2.2/CACNA1A channels (IC(50)=7.0 nM) (PubMed:10938268).<ref>PMID:10938268</ref> <ref>PMID:1352986</ref>
 
== References ==
==About this Structure==
<references/>
1V4Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V4Q OCA].  
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Kobayashi, K.]]
[[Category: Conus magus]]
[[Category: Kohno, T.]]
[[Category: Large Structures]]
[[Category: Sasaki, T.]]
[[Category: Kobayashi K]]
[[Category: Sato, K.]]
[[Category: Kohno T]]
[[Category: NH2]]
[[Category: Sasaki T]]
[[Category: calcium channel blocker]]
[[Category: Sato K]]
[[Category: cystine knot motif]]
[[Category: omega-conotoxin]]
[[Category: triple-stranded antiparallel beta-sheet]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:40:45 2008''

Latest revision as of 07:39, 23 October 2024

Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC

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