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[[Image:1vcf.gif|left|200px]]


{{Structure
==Crystal Structure of IPP isomerase at I422==
|PDB= 1vcf |SIZE=350|CAPTION= <scene name='initialview01'>1vcf</scene>, resolution 2.60&Aring;
<StructureSection load='1vcf' size='340' side='right'caption='[[1vcf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene> and <scene name='pdbligand=FMN:FLAVIN MONONUCLEOTIDE'>FMN</scene>
<table><tr><td colspan='2'>[[1vcf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VCF FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Isopentenyl-diphosphate_Delta-isomerase Isopentenyl-diphosphate Delta-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.2 5.3.3.2]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vcf OCA], [https://pdbe.org/1vcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vcf RCSB], [https://www.ebi.ac.uk/pdbsum/1vcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vcf ProSAT], [https://www.topsan.org/Proteins/RSGI/1vcf TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDI2_THET2 IDI2_THET2] Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).[HAMAP-Rule:MF_00354]<ref>PMID:17428035</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/1vcf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vcf ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of IPP isomerase at I422'''
==See Also==
 
*[[Isopentenyl-diphosphate delta-isomerase|Isopentenyl-diphosphate delta-isomerase]]
 
== References ==
==About this Structure==
<references/>
1VCF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VCF OCA].
__TOC__
[[Category: Isopentenyl-diphosphate Delta-isomerase]]
</StructureSection>
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Kuramitsu, S.]]
[[Category: Kuramitsu S]]
[[Category: Park, S Y.]]
[[Category: Park S-Y]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tame RH]]
[[Category: Tame, R H.]]
[[Category: Wada T]]
[[Category: Wada, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: CD]]
[[Category: FMN]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: tim barrel]]
 
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