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[[Image:1vgn.gif|left|200px]]


{{Structure
==Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)==
|PDB= 1vgn |SIZE=350|CAPTION= <scene name='initialview01'>1vgn</scene>, resolution 2.63&Aring;
<StructureSection load='1vgn' size='340' side='right'caption='[[1vgn]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=OPS:3-OXO-3-[(3-OXOPROPYL)SULFANYL]PROPANE-1-THIOLATE'>OPS</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
<table><tr><td colspan='2'>[[1vgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGN FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=OPS:3-OXO-3-[(3-OXOPROPYL)SULFANYL]PROPANE-1-THIOLATE'>OPS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgn OCA], [https://pdbe.org/1vgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgn RCSB], [https://www.ebi.ac.uk/pdbsum/1vgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vgn ConSurf].
<div style="clear:both"></div>


'''Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)'''
==See Also==
 
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1VGN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA].
[[Category: Large Structures]]
 
==Reference==
Irreversible inhibition of metallo-beta-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester., Kurosaki H, Yamaguchi Y, Higashi T, Soga K, Matsueda S, Yumoto H, Misumi S, Yamagata Y, Arakawa Y, Goto M, Angew Chem Int Ed Engl. 2005 Jun 20;44(25):3861-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15892033 15892033]
[[Category: Beta-lactamase]]
[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
[[Category: Single protein]]
[[Category: Arakawa Y]]
[[Category: Arakawa, Y.]]
[[Category: Goto M]]
[[Category: Goto, M.]]
[[Category: Higashi T]]
[[Category: Higashi, T.]]
[[Category: Kurosaki H]]
[[Category: Kurosaki, H.]]
[[Category: Matsueda S]]
[[Category: Matsueda, S.]]
[[Category: Misumi S]]
[[Category: Misumi, S.]]
[[Category: Soga K]]
[[Category: Soga, K.]]
[[Category: Yamagata Y]]
[[Category: Yamagata, Y.]]
[[Category: Yamaguchi Y]]
[[Category: Yamaguchi, Y.]]
[[Category: ACY]]
[[Category: OPS]]
[[Category: ZN]]
[[Category: irreversible inhibitor]]
[[Category: metallo-beta-lactamase]]
[[Category: zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:45:18 2008''

Latest revision as of 07:33, 30 October 2024

Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

1vgn, resolution 2.63Å

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