1emx: Difference between revisions
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==SOLUTION STRUCTURE OF HPTX2, A TOXIN FROM HETEROPODA VENATORIA SPIDER VENOM THAT BLOCKS KV4.2 POTASSIUM CHANNEL== | ==SOLUTION STRUCTURE OF HPTX2, A TOXIN FROM HETEROPODA VENATORIA SPIDER VENOM THAT BLOCKS KV4.2 POTASSIUM CHANNEL== | ||
<StructureSection load='1emx' size='340' side='right' caption='[[1emx | <StructureSection load='1emx' size='340' side='right'caption='[[1emx]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1emx]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1emx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Heteropoda_venatoria Heteropoda venatoria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMX FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 26 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emx OCA], [https://pdbe.org/1emx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emx RCSB], [https://www.ebi.ac.uk/pdbsum/1emx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emx ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TXHP2_HETVE TXHP2_HETVE] Inhibitor of voltage-gated potassium channels of the Kv4/KCND family. Inhibition of Kv4.3/KCND3 and Kv4.2/KCND2 is strongly voltage-dependent, while inhibition of Kv4.1/KCND1 shows less voltage-dependence. Its binding site may be near the potassium channel voltage sensor. Also blocks calcium channels.<ref>PMID:9058605</ref> [REFERENCE:2]<ref>PMID:15733564</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1emx" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Heteropoda venatoria]] | [[Category: Heteropoda venatoria]] | ||
[[Category: Bernard | [[Category: Large Structures]] | ||
[[Category: Bishoff | [[Category: Bernard C]] | ||
[[Category: Darbon | [[Category: Bishoff U]] | ||
[[Category: Ferrat | [[Category: Darbon H]] | ||
[[Category: Legros | [[Category: Ferrat G]] | ||
[[Category: Marquardt | [[Category: Legros C]] | ||
[[Category: Pongs | [[Category: Marquardt A]] | ||
[[Category: Pongs O]] | |||
