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==Solution structure of discrepin, a scorpion venom toxin blocking K+ channels.==
==Solution structure of discrepin, a scorpion venom toxin blocking K+ channels.==
<StructureSection load='2axk' size='340' side='right' caption='[[2axk]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2axk' size='340' side='right'caption='[[2axk]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2axk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXK FirstGlance]. <br>
<table><tr><td colspan='2'>[[2axk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tityus_discrepans Tityus discrepans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXK FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axk RCSB], [http://www.ebi.ac.uk/pdbsum/2axk PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axk OCA], [https://pdbe.org/2axk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axk RCSB], [https://www.ebi.ac.uk/pdbsum/2axk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KA156_TITDI KA156_TITDI]] Irreversibly blocks the A-type voltage-gated potassium channels in rat cerebellum granular cells.<ref>PMID:15369825</ref> <ref>PMID:16460026</ref>
[https://www.uniprot.org/uniprot/KA156_TITDI KA156_TITDI] Irreversibly blocks the A-type voltage-gated potassium channels in rat cerebellum granular cells.<ref>PMID:15369825</ref> <ref>PMID:16460026</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2axk" style="background-color:#fffaf0;"></div>
==See Also==
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Corzo, G]]
[[Category: Large Structures]]
[[Category: Delepierre, M]]
[[Category: Tityus discrepans]]
[[Category: Martin-Eauclaire, M F]]
[[Category: Corzo G]]
[[Category: Murgia, A R]]
[[Category: D'Suze G]]
[[Category: Possani, L D]]
[[Category: Delepierre M]]
[[Category: Prestipino, G]]
[[Category: Martin-Eauclaire M-F]]
[[Category: Prochnicka-Chalufour, A]]
[[Category: Murgia AR]]
[[Category: Satake, H]]
[[Category: Possani LD]]
[[Category: Suze, G D]]
[[Category: Prestipino G]]
[[Category: A-current]]
[[Category: Prochnicka-Chalufour A]]
[[Category: Discrepin]]
[[Category: Satake H]]
[[Category: K+-channel]]
[[Category: Scorpion toxin]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/2axk"