4x3u: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4x3u is ~~ON HOLD until Paper Publication~~

==Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin==

~~Authors~~: ~~Ren~~, C., ~~Zhou~~, M.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[4x3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3U OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4X3U FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~chromobox homolog 7~~ (~~CBX7~~) ~~chromodomain with Suramin~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SVR:8,8-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC+ACID'>SVR</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4x3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3u OCA], [https://pdbe.org/4x3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x3u RCSB], [https://www.ebi.ac.uk/pdbsum/4x3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x3u ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CBX7_MOUSE CBX7_MOUSE] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:16537902</ref> <ref>PMID:20541999</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Ren C]]

[[Category: Zhou MM]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4x3u is ON HOLD  until Paper Publication
+==Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin==
+<StructureSection load='4x3u' size='340' side='right'caption='[[4x3u]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
-Authors: Ren, C., Zhou, M.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4x3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X3U FirstGlance]. <br>
-Description: Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SVR:8,8-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC+ACID'>SVR</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3u OCA], [https://pdbe.org/4x3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x3u RCSB], [https://www.ebi.ac.uk/pdbsum/4x3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x3u ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CBX7_MOUSE CBX7_MOUSE] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:16537902</ref> <ref>PMID:20541999</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Ren C]]
+[[Category: Zhou MM]]