4xal: Difference between revisions
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==Crystal structure of the conserved core domain of VP22 from HSV-1== | |||
<StructureSection load='4xal' size='340' side='right'caption='[[4xal]], [[Resolution|resolution]] 1.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XAL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.869Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xal OCA], [https://pdbe.org/4xal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xal RCSB], [https://www.ebi.ac.uk/pdbsum/4xal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xal ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VP22_HHV11 VP22_HHV11] Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network. Finally, may prevent nucleosomal deposition onto the viral genome by interacting with and inhibiting host SET.<ref>PMID:12917472</ref> <ref>PMID:15795259</ref> <ref>PMID:22951838</ref> <ref>PMID:22993164</ref> <ref>PMID:24131716</ref> <ref>PMID:9658087</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human alphaherpesvirus 1 strain 17]] | |||
[[Category: Large Structures]] | |||
[[Category: Dahlroth SL]] | |||
[[Category: Hew K]] | |||
[[Category: Nordlund P]] | |||
Latest revision as of 09:02, 20 March 2024
Crystal structure of the conserved core domain of VP22 from HSV-1
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