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[[Image:1wl8.gif|left|200px]]


{{Structure
==Crystal structure of PH1346 protein from Pyrococcus horikoshii==
|PDB= 1wl8 |SIZE=350|CAPTION= <scene name='initialview01'>1wl8</scene>, resolution 1.45&Aring;
<StructureSection load='1wl8' size='340' side='right'caption='[[1wl8]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
<table><tr><td colspan='2'>[[1wl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WL8 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/GMP_synthase_(glutamine-hydrolyzing) GMP synthase (glutamine-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.5.2 6.3.5.2]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wl8 OCA], [https://pdbe.org/1wl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wl8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wl8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wl8 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GUAAA_PYRHO GUAAA_PYRHO] Catalyzes the synthesis of GMP from XMP (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/1wl8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wl8 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of PH1346 protein from Pyrococcus horikoshii'''
==See Also==
 
*[[GMP synthase|GMP synthase]]
 
__TOC__
==About this Structure==
</StructureSection>
1WL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WL8 OCA].
[[Category: Large Structures]]
[[Category: GMP synthase (glutamine-hydrolyzing)]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
[[Category: Single protein]]
[[Category: Kunishima N]]
[[Category: Kunishima, N.]]
[[Category: Lokanath NK]]
[[Category: Lokanath, N K.]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: ACY]]
[[Category: CL]]
[[Category: gatase]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:58:25 2008''
Retrieved from "https://proteopedia.org/1wl8"