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==Structure of E. coli Transcriptional Regulator RutR with bound uracil==
==Structure of E. coli Transcriptional Regulator RutR with bound uracil==
<StructureSection load='4jyk' size='340' side='right' caption='[[4jyk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4jyk' size='340' side='right'caption='[[4jyk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JYK FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JYK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b1013, JW0998, rutR, ycdC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jyk RCSB], [http://www.ebi.ac.uk/pdbsum/4jyk PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyk OCA], [https://pdbe.org/4jyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jyk RCSB], [https://www.ebi.ac.uk/pdbsum/4jyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jyk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI]] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref>
[https://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref>  
 
==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli K-12]]
[[Category: Almo, S C]]
[[Category: Large Structures]]
[[Category: Cooper, D R]]
[[Category: Almo SC]]
[[Category: Knapik, A A]]
[[Category: Cooper DR]]
[[Category: Minor, W]]
[[Category: Knapik AA]]
[[Category: Structural genomic]]
[[Category: Minor W]]
[[Category: Osinski,T]]
[[Category: Osinski T]]
[[Category: Petkowski, J J]]
[[Category: Petkowski JJ]]
[[Category: Porebski, P J]]
[[Category: Porebski PJ]]
[[Category: Helix-turn-helix]]
[[Category: Nysgrc]]
[[Category: Psi-biology]]
[[Category: Transcription regulator]]
[[Category: Transcriptional regulator]]
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