1x61: Difference between revisions

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[[Image:1x61.gif|left|200px]]


{{Structure
==Solution structure of the first LIM domain of thyroid receptor interacting protein 6 (TRIP6)==
|PDB= 1x61 |SIZE=350|CAPTION= <scene name='initialview01'>1x61</scene>
<StructureSection load='1x61' size='340' side='right'caption='[[1x61]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
<table><tr><td colspan='2'>[[1x61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X61 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= TRIP6, OIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x61 OCA], [https://pdbe.org/1x61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x61 RCSB], [https://www.ebi.ac.uk/pdbsum/1x61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x61 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x61 TOPSAN]</span></td></tr>
 
</table>
'''Solution structure of the first LIM domain of thyroid receptor interacting protein 6 (TRIP6)'''
== Function ==
 
[https://www.uniprot.org/uniprot/TRIP6_HUMAN TRIP6_HUMAN] Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.<ref>PMID:15489293</ref> <ref>PMID:14688263</ref> <ref>PMID:16624523</ref> <ref>PMID:19017743</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1X61 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X61 OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x61_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x61 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Nagashima, T.]]
[[Category: Nagashima T]]
[[Category: Qin, X R.]]
[[Category: Qin XR]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: lim domain]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: opa-interacting protein 1]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: thyroid receptor interacting protein 6 (trip6)]]
[[Category: zyxin related protein 1 (zrp-1)]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:05:34 2008''

Latest revision as of 14:01, 9 May 2024

Solution structure of the first LIM domain of thyroid receptor interacting protein 6 (TRIP6)

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