1x68: Difference between revisions

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[[Image:1x68.gif|left|200px]]


{{Structure
==Solution structures of the C-terminal LIM domain of human FHL5 protein==
|PDB= 1x68 |SIZE=350|CAPTION= <scene name='initialview01'>1x68</scene>
<StructureSection load='1x68' size='340' side='right'caption='[[1x68]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
<table><tr><td colspan='2'>[[1x68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X68 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= FHL5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x68 OCA], [https://pdbe.org/1x68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x68 RCSB], [https://www.ebi.ac.uk/pdbsum/1x68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x68 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x68 TOPSAN]</span></td></tr>
 
</table>
'''Solution structures of the C-terminal LIM domain of human FHL5 protein'''
== Function ==
 
[https://www.uniprot.org/uniprot/FHL5_HUMAN FHL5_HUMAN] May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.<ref>PMID:11327716</ref>
 
== Evolutionary Conservation ==
==Disease==
[[Image:Consurf_key_small.gif|200px|right]]
Known diseases associated with this structure: Alpha-1-antichymotrypsin deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107280 107280]], Cerebrovascular disease, occlusive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107280 107280]]
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x68_consurf.spt"</scriptWhenChecked>
1X68 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X68 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x68 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Nameki, N.]]
[[Category: Nameki N]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sasagawa A]]
[[Category: Sasagawa, A.]]
[[Category: Sato M]]
[[Category: Sato, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: an actin-interacting protein]]
[[Category: four-and-a-half lim protein 5]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: zinc finger domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:05:39 2008''

Latest revision as of 14:01, 9 May 2024

Solution structures of the C-terminal LIM domain of human FHL5 protein

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