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==Crystal structure of RIAM TBS1 in complex with talin R7R8 domains==
==Crystal structure of RIAM TBS1 in complex with talin R7R8 domains==
<StructureSection load='4w8p' size='340' side='right' caption='[[4w8p]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4w8p' size='340' side='right'caption='[[4w8p]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4w8p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W8P FirstGlance]. <br>
<table><tr><td colspan='2'>[[4w8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W8P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w8p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w8p RCSB], [http://www.ebi.ac.uk/pdbsum/4w8p PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w8p OCA], [https://pdbe.org/4w8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w8p RCSB], [https://www.ebi.ac.uk/pdbsum/4w8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w8p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. [[http://www.uniprot.org/uniprot/AB1IP_MOUSE AB1IP_MOUSE]] Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion (By similarity).  
[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4w8p" style="background-color:#fffaf0;"></div>
==See Also==
*[[Talin|Talin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chang, Y C.E]]
[[Category: Large Structures]]
[[Category: Wu, J]]
[[Category: Mus musculus]]
[[Category: Zhang, H]]
[[Category: Chang YCE]]
[[Category: Peptide binding protein]]
[[Category: Wu J]]
[[Category: R7r8]]
[[Category: Zhang H]]
[[Category: R8]]
[[Category: Riam]]
[[Category: Rod domain]]
[[Category: Talin]]
[[Category: Tbs1]]
Retrieved from "https://proteopedia.org/4w8p"