1xeq: Difference between revisions

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[[Image:1xeq.gif|left|200px]]


{{Structure
==Crystal tructure of RNA binding domain of influenza B virus non-structural protein==
|PDB= 1xeq |SIZE=350|CAPTION= <scene name='initialview01'>1xeq</scene>, resolution 2.10&Aring;
<StructureSection load='1xeq' size='340' side='right'caption='[[1xeq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BR:BROMIDE ION'>BR</scene>
<table><tr><td colspan='2'>[[1xeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Lee/1940) Influenza B virus (B/Lee/1940)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEQ FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= 8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11520 Influenza B virus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xeq OCA], [https://pdbe.org/1xeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xeq RCSB], [https://www.ebi.ac.uk/pdbsum/1xeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xeq ProSAT], [https://www.topsan.org/Proteins/NESGC/1xeq TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>


'''Crystal tructure of RNA binding domain of influenza B virus non-structural protein'''
==See Also==
 
*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
1XEQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEQ OCA].
__TOC__
[[Category: Influenza b virus]]
</StructureSection>
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Khan, J A.]]
[[Category: Khan JA]]
[[Category: Krug, R M.]]
[[Category: Krug RM]]
[[Category: Montelione, G T.]]
[[Category: Montelione GT]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Tong L]]
[[Category: Tong, L.]]
[[Category: Yin C]]
[[Category: Yin, C.]]
[[Category: BR]]
[[Category: influenza b virus]]
[[Category: nesg]]
[[Category: non-structural protein]]
[[Category: northeast structural genomics consortium]]
[[Category: ns1b]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: rna binding domain]]
[[Category: structural genomic]]
 
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Retrieved from "https://proteopedia.org/1xeq"