1y17: Difference between revisions

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[[Image:1y17.gif|left|200px]]


{{Structure
==crystal structure of Aa-X-bp-II, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus==
|PDB= 1y17 |SIZE=350|CAPTION= <scene name='initialview01'>1y17</scene>, resolution 2.40&Aring;
<StructureSection load='1y17' size='340' side='right'caption='[[1y17]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
<table><tr><td colspan='2'>[[1y17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y17 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y17 OCA], [https://pdbe.org/1y17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y17 RCSB], [https://www.ebi.ac.uk/pdbsum/1y17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y17 ProSAT]</span></td></tr>
 
</table>
'''crystal structure of Aa-X-bp-II, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus'''
== Function ==
 
[https://www.uniprot.org/uniprot/SLAA_DEIAC SLAA_DEIAC] Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX and factor X in the presence of calcium with a 1 to 1 stoichiometry. Also inhibits platelet aggregation by binding to platelet glycoprotein Ibalpha (GP1BA) and functioning as a blocker of vWF. Is devoid of hemorrhagic and lethal activities. Possess antithrombotic and thrombolytic activities. Also hydrolyzes the Aalpha-chain of fibrinogen. Does not affect the Bbeta-chain and the gamma chain (By similarity).
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1Y17 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y17 OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y17_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y17 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Deinagkistrodon acutus]]
[[Category: Deinagkistrodon acutus]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Liang, Z.]]
[[Category: Liang Z]]
[[Category: Liu, S.]]
[[Category: Liu S]]
[[Category: Mo, X.]]
[[Category: Mo X]]
[[Category: Niu, L.]]
[[Category: Niu L]]
[[Category: Teng, M.]]
[[Category: Teng M]]
[[Category: Yu, X.]]
[[Category: Yu X]]
[[Category: Zang, J.]]
[[Category: Zang J]]
[[Category: Zhao, W.]]
[[Category: Zhao W]]
[[Category: Zhu, Z.]]
[[Category: Zhu Z]]
[[Category: CA]]
[[Category: aa-x-bp-ii]]
[[Category: agkistrodon acutus]]
[[Category: c-type lectin-like protein]]
[[Category: snake venom]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:17:13 2008''
Retrieved from "https://proteopedia.org/1y17"