4rmj: Difference between revisions

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'''Unreleased structure'''


The entry 4rmj is ON HOLD  until Paper Publication
==Human Sirt2 in complex with ADP ribose and nicotinamide==
<StructureSection load='4rmj' size='340' side='right'caption='[[4rmj]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4rmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RMJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmj OCA], [https://pdbe.org/4rmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rmj RCSB], [https://www.ebi.ac.uk/pdbsum/4rmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rmj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>


Authors: Rumpf, T., Schiedel, M., Karaman, B., Roessler, C., North, B.J., Lehotzky, A., Olah, J., Ladwein, K.I., Schmidtkunz, K., Gajer, M., Pannek, M., Steegborn, C., Sinclair, D.A., Gerhardt, S., Ovadi, J., Schutkowski, M., Sippl, W., Einsle, O., Jung, M.
==See Also==
 
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
Description: Human Sirt2 in complex with ADP ribose and nicotinamide
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Schmidtkunz, K]]
__TOC__
[[Category: Sinclair, D.A]]
</StructureSection>
[[Category: Rumpf, T]]
[[Category: Homo sapiens]]
[[Category: Pannek, M]]
[[Category: Large Structures]]
[[Category: Roessler, C]]
[[Category: Einsle O]]
[[Category: Sippl, W]]
[[Category: Gajer M]]
[[Category: Gerhardt, S]]
[[Category: Gerhardt S]]
[[Category: Jung, M]]
[[Category: Jung M]]
[[Category: Lehotzky, A]]
[[Category: Karaman B]]
[[Category: Karaman, B]]
[[Category: Ladwein KI]]
[[Category: Steegborn, C]]
[[Category: Lehotzky A]]
[[Category: North, B.J]]
[[Category: North BJ]]
[[Category: Schutkowski, M]]
[[Category: Olah J]]
[[Category: Olah, J]]
[[Category: Ovadi J]]
[[Category: Gajer, M]]
[[Category: Pannek M]]
[[Category: Ovadi, J]]
[[Category: Roessler C]]
[[Category: Schiedel, M]]
[[Category: Rumpf T]]
[[Category: Ladwein, K.I]]
[[Category: Schiedel M]]
[[Category: Einsle, O]]
[[Category: Schmidtkunz K]]
[[Category: Schutkowski M]]
[[Category: Sinclair DA]]
[[Category: Sippl W]]
[[Category: Steegborn C]]
Retrieved from "https://proteopedia.org/4rmj"