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[[Image:1y8t.gif|left|200px]]


{{Structure
==Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form==
|PDB= 1y8t |SIZE=350|CAPTION= <scene name='initialview01'>1y8t</scene>, resolution 2.00&Aring;
<StructureSection load='1y8t' size='340' side='right'caption='[[1y8t]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[1y8t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y8T FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8t OCA], [https://pdbe.org/1y8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y8t RCSB], [https://www.ebi.ac.uk/pdbsum/1y8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8t ProSAT], [https://www.topsan.org/Proteins/TBSGC/1y8t TOPSAN]</span></td></tr>
 
</table>
'''Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form'''
== Function ==
 
[https://www.uniprot.org/uniprot/PEPD_MYCTU PEPD_MYCTU] Required for virulence (PubMed:18479146). Acts both as a protease, which degrades and/or refolds damaged substrate targets, and as a chaperone (PubMed:18479146, PubMed:20061478). Plays an important role in the stress response network mediated through the two-component regulatory system MprAB and SigE signaling networks (PubMed:20061478). May utilize its PDZ domain to recognize and process misfolded proteins at the cell membrane, leading to activation of the MprAB and SigE signaling pathways and subsequent establishment of a positive feedback loop that facilitates bacterial adaptation (PubMed:20061478). Interacts with and potentially cleaves several proteins, including the 35 kDa antigen PspA (PubMed:21445360). Proteolytic cleavage of PspA may help to maintain cell envelope homeostasis in Mycobacterium and regulate specific stress response pathways during periods of extracytoplasmic stress (PubMed:21445360). In vitro, exhibits proteolytic activity against the artificial substrate beta-casein (PubMed:18479146, PubMed:20061478).<ref>PMID:18479146</ref> <ref>PMID:20061478</ref> <ref>PMID:21445360</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1Y8T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8T OCA].  
Check<jmol>
[[Category: Mycobacterium tuberculosis h37rv]]
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y8/1y8t_consurf.spt"</scriptWhenChecked>
[[Category: MohamedMohaideen, N N.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Palaninathan, S K.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Sacchettini, J C.]]
  </jmolCheckbox>
[[Category: TBSGC, TB Structural Genomics Consortium.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y8t ConSurf].
[[Category: protein structure initiative]]
<div style="clear:both"></div>
[[Category: psi]]
== References ==
[[Category: serine protease]]
<references/>
[[Category: structural genomic]]
__TOC__
[[Category: tb structural genomics consortium]]
</StructureSection>
[[Category: tbsgc]]
[[Category: Large Structures]]
 
[[Category: Mycobacterium tuberculosis H37Rv]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:19:47 2008''
[[Category: MohamedMohaideen NN]]
[[Category: Palaninathan SK]]
[[Category: Sacchettini JC]]

Latest revision as of 07:31, 9 October 2024

Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form

1y8t, resolution 2.00Å

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