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[[Image:1y96.gif|left|200px]]


{{Structure
==crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex==
|PDB= 1y96 |SIZE=350|CAPTION= <scene name='initialview01'>1y96</scene>, resolution 2.002&Aring;
<StructureSection load='1y96' size='340' side='right'caption='[[1y96]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.002&#8491;</td></tr>
|GENE= GEMIN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), GEMIN7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [https://pdbe.org/1y96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [https://www.ebi.ac.uk/pdbsum/1y96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y96 ProSAT]</span></td></tr>
}}
</table>
 
== Function ==
'''crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex'''
[https://www.uniprot.org/uniprot/GEMI6_HUMAN GEMI6_HUMAN] The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.<ref>PMID:11748230</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The survival of motor neurons (SMN) protein, product of the disease gene of the common neurodegenerative disease spinal muscular atrophy, is part of the large multiprotein "SMN complex." The SMN complex functions as an assembly machine for small nuclear ribonucleoproteins (snRNPs)-the major components of the spliceosome. Here, we report the crystal structure of two components of the human SMN complex, Gemin6 and Gemin7. Although Gemin6 and Gemin7 have no significant sequence similarity with Sm proteins, both adopt canonical Sm folds. Moreover, Gemin6 and Gemin7 exist as a heterodimer, and interact with each other via an interface similar to that which mediates interactions among the Sm proteins. Together with binding experiments that show that the Gemin6/Gemin7 complex binds to Sm proteins, these findings provide a framework for considering how the SMN complex, with Gemin6 and Gemin7 as tools, might organize Sm proteins for formation of Sm rings on snRNA targets.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y9/1y96_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
1Y96 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y96 ConSurf].
The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure., Ma Y, Dostie J, Dreyfuss G, Van Duyne GD, Structure. 2005 Jun;13(6):883-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15939020 15939020]
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Dostie, J.]]
[[Category: Dostie J]]
[[Category: Dreyfuss, G.]]
[[Category: Dreyfuss G]]
[[Category: Duyne, G D.Van.]]
[[Category: Ma Y]]
[[Category: Ma, Y.]]
[[Category: Van Duyne GD]]
[[Category: protein complex]]
[[Category: sm fold]]
 
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Retrieved from "https://proteopedia.org/1y96"