2fy1: Difference between revisions
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==A dual mode of RNA recognition by the RBMY protein== | ==A dual mode of RNA recognition by the RBMY protein== | ||
<StructureSection load='2fy1' size='340' side='right' caption='[[2fy1 | <StructureSection load='2fy1' size='340' side='right'caption='[[2fy1]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2fy1]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2fy1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FY1 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fy1 OCA], [https://pdbe.org/2fy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fy1 RCSB], [https://www.ebi.ac.uk/pdbsum/2fy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fy1 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RBY1A_HUMAN RBY1A_HUMAN] RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.<ref>PMID:8269511</ref> <ref>PMID:12165565</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fy1_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fy1_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fy1 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | == References == | ||
| Line 22: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Allain | [[Category: Large Structures]] | ||
[[Category: Bourgois | [[Category: Synthetic construct]] | ||
[[Category: Elliot | [[Category: Allain FHT]] | ||
[[Category: Kister | [[Category: Bourgois C]] | ||
[[Category: Skrisovska | [[Category: Elliot D]] | ||
[[Category: Stefl | [[Category: Kister L]] | ||
[[Category: Stevenin | [[Category: Skrisovska L]] | ||
[[Category: Wenter | [[Category: Stefl R]] | ||
[[Category: Stevenin J]] | |||
[[Category: Wenter P]] | |||
Latest revision as of 06:40, 1 May 2024
A dual mode of RNA recognition by the RBMY protein
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