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==Crystal structure of the p73-ASPP2 complex at 2.6A resolution==
==Crystal structure of the p73-ASPP2 complex at 2.6A resolution==
<StructureSection load='4a63' size='340' side='right' caption='[[4a63]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
<StructureSection load='4a63' size='340' side='right'caption='[[4a63]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a63]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A63 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a63]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A63 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dxs|1dxs]], [[2wqj|2wqj]], [[1ycs|1ycs]], [[2xwc|2xwc]], [[2wqi|2wqi]], [[2uwq|2uwq]], [[2wtt|2wtt]], [[1cok|1cok]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a63 RCSB], [http://www.ebi.ac.uk/pdbsum/4a63 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a63 OCA], [https://pdbe.org/4a63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a63 RCSB], [https://www.ebi.ac.uk/pdbsum/4a63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a63 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> [[http://www.uniprot.org/uniprot/ASPP2_HUMAN ASPP2_HUMAN]] Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.<ref>PMID:11684014</ref> <ref>PMID:12694406</ref> <ref>PMID:19377511</ref> 
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4a63" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C]]
[[Category: Large Structures]]
[[Category: Bountra, C]]
[[Category: Arrowsmith C]]
[[Category: Bullock, A N]]
[[Category: Bountra C]]
[[Category: Canning, P]]
[[Category: Bullock AN]]
[[Category: Cooper, C D.O]]
[[Category: Canning P]]
[[Category: Delft, F Von]]
[[Category: Cooper CDO]]
[[Category: Edwards, A]]
[[Category: Edwards A]]
[[Category: Keates, T]]
[[Category: Keates T]]
[[Category: Krojer, T]]
[[Category: Krojer T]]
[[Category: Muniz, J]]
[[Category: Muniz J]]
[[Category: Salah, E]]
[[Category: Salah E]]
[[Category: Savitsky, P]]
[[Category: Savitsky P]]
[[Category: Sharpe, T]]
[[Category: Sharpe T]]
[[Category: Vollmar, M]]
[[Category: Vollmar M]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Ankyrin]]
[[Category: Von Delft F]]
[[Category: Apoptosis regulatory protein]]
[[Category: Cell cycle]]
[[Category: Tp53bp2]]
[[Category: Tumour suppressor]]
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