1ysv: Difference between revisions
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==Solution structure of the central region of the human GluR-B R/G pre-mRNA== | |||
<StructureSection load='1ysv' size='340' side='right'caption='[[1ysv]]' scene=''> | |||
== Structural highlights == | |||
| | <table><tr><td colspan='2'>[[1ysv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YSV FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ysv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysv OCA], [https://pdbe.org/1ysv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ysv RCSB], [https://www.ebi.ac.uk/pdbsum/1ysv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysv ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
''' | == Publication Abstract from PubMed == | ||
== | |||
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2. | Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2. | ||
A novel RNA pentaloop fold involved in targeting ADAR2.,Stefl R, Allain FH RNA. 2005 May;11(5):592-7. PMID:15840813<ref>PMID:15840813</ref> | |||
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1ysv" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Allain FH]] | |||
[[Category: Stefl R]] | |||
Latest revision as of 09:31, 6 December 2023
Solution structure of the central region of the human GluR-B R/G pre-mRNA
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