4v3c: Difference between revisions

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'''Unreleased structure'''


The entry 4v3c is ON HOLD  until Paper Publication
==The structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis in complex with the donor product CMP==
<StructureSection load='4v3c' size='340' side='right'caption='[[4v3c]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4v3c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pasteurella_dagmatis Pasteurella dagmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V3C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v3c OCA], [https://pdbe.org/4v3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v3c RCSB], [https://www.ebi.ac.uk/pdbsum/4v3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v3c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/K9UUI6_9PAST K9UUI6_9PAST]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structure-guided active-site redesign of a family GT-80 beta-D-galactoside sialyltransferase (from Pasteurella dagmatis) to change enzyme regioselectivity from alpha-2,3 in the wild type to alpha-2,6 in a P7H-M117A double mutant is reported. Biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering.


Authors: Pavkov-Keller, T., Schmoelzer, K., Czabany, T., Luley-Goedl, C., Ribitsch, D., Schwab, H., Nidetzky, B., Gruber, K.
Complete switch from alpha-2,3- to alpha-2,6-regioselectivity in Pasteurella dagmatis beta-D-galactoside sialyltransferase by active-site redesign.,Schmolzer K, Czabany T, Luley-Goedl C, Pavkov-Keller T, Ribitsch D, Schwab H, Gruber K, Weber H, Nidetzky B Chem Commun (Camb). 2015 Feb 21;51(15):3083-6. doi: 10.1039/c4cc09772f. PMID:25619424<ref>PMID:25619424</ref>


Description: The structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis in complex with the donor product CMP
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Ribitsch, D]]
<div class="pdbe-citations 4v3c" style="background-color:#fffaf0;"></div>
[[Category: Luley-Goedl, C]]
 
[[Category: Nidetzky, B]]
==See Also==
[[Category: Czabany, T]]
*[[Sialyltransferase 3D structures|Sialyltransferase 3D structures]]
[[Category: Pavkov-Keller, T]]
== References ==
[[Category: Schmoelzer, K]]
<references/>
[[Category: Gruber, K]]
__TOC__
[[Category: Schwab, H]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Pasteurella dagmatis]]
[[Category: Czabany T]]
[[Category: Gruber K]]
[[Category: Luley-Goedl C]]
[[Category: Nidetzky B]]
[[Category: Pavkov-Keller T]]
[[Category: Ribitsch D]]
[[Category: Schmoelzer K]]
[[Category: Schwab H]]
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