1z3f: Difference between revisions

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[[Image:1z3f.gif|left|200px]]


{{Structure
==Structure of ellipticine in complex with a 6-bp DNA==
|PDB= 1z3f |SIZE=350|CAPTION= <scene name='initialview01'>1z3f</scene>, resolution 1.50&Aring;
<StructureSection load='1z3f' size='340' side='right'caption='[[1z3f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene> and <scene name='pdbligand=CO:COBALT (II) ION'>CO</scene>
<table><tr><td colspan='2'>[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3F FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3f OCA], [https://pdbe.org/1z3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3f RCSB], [https://www.ebi.ac.uk/pdbsum/1z3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3f ProSAT]</span></td></tr>
 
</table>
'''Structure of ellipticine in complex with a 6-bp DNA'''
__TOC__
 
</StructureSection>
 
[[Category: Large Structures]]
==Overview==
[[Category: Aymami J]]
Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.
[[Category: Canals A]]
 
[[Category: Coll M]]
==About this Structure==
[[Category: Purciolas M]]
1Z3F is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA].
 
==Reference==
The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs., Canals A, Purciolas M, Aymami J, Coll M, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15983425 15983425]
[[Category: Protein complex]]
[[Category: Aymami, J.]]
[[Category: Canals, A.]]
[[Category: Coll, M.]]
[[Category: Purciolas, M.]]
[[Category: CO]]
[[Category: EL]]
[[Category: anticancer]]
[[Category: dna binding]]
[[Category: drug design]]
[[Category: ellipticine]]
[[Category: intercalator]]
 
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Retrieved from "https://proteopedia.org/1z3f"