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==Crystal structure of Protein Related to DAN and Cerberus (PRDC)==
==Crystal structure of Protein Related to DAN and Cerberus (PRDC)==
<StructureSection load='4jph' size='340' side='right' caption='[[4jph]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='4jph' size='340' side='right'caption='[[4jph]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jph]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JPH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jph]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JPH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Grem2, Cktsf1b2, Prdc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jph RCSB], [http://www.ebi.ac.uk/pdbsum/4jph PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jph OCA], [https://pdbe.org/4jph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jph RCSB], [https://www.ebi.ac.uk/pdbsum/4jph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jph ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GREM2_MOUSE GREM2_MOUSE]] Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells.<ref>PMID:15039429</ref>
[https://www.uniprot.org/uniprot/GREM2_MOUSE GREM2_MOUSE] Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells.<ref>PMID:15039429</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4jph" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Deng, X]]
[[Category: Deng X]]
[[Category: Kattamuri, C]]
[[Category: Kattamuri C]]
[[Category: Nolan, K T]]
[[Category: Nolan KT]]
[[Category: Thompson, T B]]
[[Category: Thompson TB]]
[[Category: Bmp antagonist]]
[[Category: Bmp-2]]
[[Category: Bmp-4]]
[[Category: Bmp-7]]
[[Category: Can domain]]
[[Category: Cystine knot]]
[[Category: Cytokine]]
[[Category: Dan domain]]
[[Category: Extracellular]]
[[Category: Gdf-5]]
[[Category: Gsh]]
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