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==Crystal structure of HCoV-OC43 N-NTD complexed with GMP==
==Crystal structure of HCoV-OC43 N-NTD complexed with GMP==
<StructureSection load='4lm9' size='340' side='right' caption='[[4lm9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4lm9' size='340' side='right'caption='[[4lm9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lm9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LM9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_OC43 Human coronavirus OC43]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LM9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.601&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lm7|4lm7]], [[4lmc|4lmc]], [[4lmt|4lmt]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lm9 RCSB], [http://www.ebi.ac.uk/pdbsum/4lm9 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lm9 OCA], [https://pdbe.org/4lm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lm9 RCSB], [https://www.ebi.ac.uk/pdbsum/4lm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lm9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q6SA23_CVHOC Q6SA23_CVHOC]] Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid (By similarity).[PIRNR:PIRNR003888]  
[https://www.uniprot.org/uniprot/NCAP_CVHOC NCAP_CVHOC] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Attenuates the stress granules formation by reducing host G3BP1 access to host mRNAs under stress conditions (PubMed:36534661).[HAMAP-Rule:MF_04096]<ref>PMID:36534661</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4lm9" style="background-color:#fffaf0;"></div>
==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hou, M H]]
[[Category: Human coronavirus OC43]]
[[Category: Lin, S Y]]
[[Category: Large Structures]]
[[Category: Liu, C L]]
[[Category: Hou MH]]
[[Category: Hcov-oc43 nucleocapsid protein]]
[[Category: Lin SY]]
[[Category: N-terminal domain]]
[[Category: Liu CL]]
[[Category: Rna binding]]
[[Category: Rna binding protein]]
Retrieved from "https://proteopedia.org/4lm9"