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==Crystal structure of a putative uncharacterized protein from Mycobacterium tuberculosis==
==Crystal structure of a putative uncharacterized protein from Mycobacterium tuberculosis==
<StructureSection load='4q6u' size='340' side='right' caption='[[4q6u]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4q6u' size='340' side='right'caption='[[4q6u]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4q6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6U FirstGlance]. <br>
<table><tr><td colspan='2'>[[4q6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q6U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6u RCSB], [http://www.ebi.ac.uk/pdbsum/4q6u PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6u OCA], [https://pdbe.org/4q6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6u RCSB], [https://www.ebi.ac.uk/pdbsum/4q6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/I6YCP0_MYCTU I6YCP0_MYCTU]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The genome of the human pathogen Mycobacterium tuberculosis (Mtb) encodes approximately 4,400 proteins, but one third of them have unknown functions. We solved the crystal structure of Rv3651, a hypothetical protein with no discernible similarity to proteins with known function. Rv3651 has a three-domain architecture that combines one cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA (GAF) domain and two Per-ARNT-Sim (PAS) domains. GAF and PAS domains are sensor domains that are typically linked to signaling effector molecules. Unlike these sensor-effector proteins, Rv3651 is an unusual sensor domain-only protein with highly divergent sequence. The structure suggests that Rv3651 integrates multiple different signals and serves as a scaffold to facilitate signal transfer.
Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.,Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5. PMID:29119630<ref>PMID:29119630</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4q6u" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Structural genomic]]
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis CDC1551]]
[[Category: Seattle structural genoics for infectious disease]]
[[Category: Ssgcid]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/4q6u"