4ksd: Difference between revisions

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==Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain==
==Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain==
<StructureSection load='4ksd' size='340' side='right' caption='[[4ksd]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<StructureSection load='4ksd' size='340' side='right'caption='[[4ksd]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KSD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSD FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ksb|4ksb]], [[4ksc|4ksc]], [[4lsg|4lsg]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1001&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), r2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9844 Lama glama])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [https://pdbe.org/4ksd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [https://www.ebi.ac.uk/pdbsum/4ksd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksd ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [http://www.ebi.ac.uk/pdbsum/4ksd PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4ksd" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Lama glama]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Xenobiotic-transporting ATPase]]
[[Category: Caya A]]
[[Category: Caya, A]]
[[Category: Chang G]]
[[Category: Chang, G]]
[[Category: Cregger C]]
[[Category: Cregger, C]]
[[Category: Doshi R]]
[[Category: Doshi, R]]
[[Category: Falson P]]
[[Category: Falson, P]]
[[Category: Govaerts C]]
[[Category: Govaerts, C]]
[[Category: Grimard V]]
[[Category: Grimard, V]]
[[Category: Lee C-W]]
[[Category: Lee, C-W]]
[[Category: Martinez L]]
[[Category: Martinez, L]]
[[Category: Pardon E]]
[[Category: Pardon, E]]
[[Category: Steyaert J]]
[[Category: Steyaert, J]]
[[Category: Swartz DJ]]
[[Category: Swartz, D J]]
[[Category: Szewczyk P]]
[[Category: Szewczyk, P]]
[[Category: Urbatsch I]]
[[Category: Urbatsch, I]]
[[Category: Villaluz M]]
[[Category: Villaluz, M]]
[[Category: Ward A]]
[[Category: Ward, A]]
[[Category: Atp binding]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Transport protein]]
[[Category: Transporter]]
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