4xc2: Difference between revisions

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'''Unreleased structure'''


The entry 4xc2 is ON HOLD  until Paper Publication
==Crystal structure of GABARAP in complex with KBTBD6 LIR peptide==
<StructureSection load='4xc2' size='340' side='right'caption='[[4xc2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4xc2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc2 OCA], [https://pdbe.org/4xc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc2 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The small Rho GTPase RAC1 is an essential regulator of cellular signaling that controls actin rearrangements and cell motility. Here, we identify a novel CUL3 RING ubiquitin ligase complex, containing the substrate adaptors KBTBD6 and KBTBD7, that mediates ubiquitylation and proteasomal degradation of TIAM1, a RAC1-specific GEF. Increasing the abundance of TIAM1 by depletion of KBTBD6 and/or KBTBD7 leads to elevated RAC1 activity, changes in actin morphology, loss of focal adhesions, reduced proliferation, and enhanced invasion. KBTBD6 and KBTBD7 employ ATG8 family-interacting motifs to bind preferentially to GABARAP proteins. Surprisingly, ubiquitylation and degradation of TIAM1 by CUL3KBTBD6/KBTBD7 depends on its binding to GABARAP proteins. Our study reveals that recruitment of CUL3KBTBD6/KBTBD7 to GABARAP-containing vesicles regulates the abundance of membrane-associated TIAM1 and subsequently spatially restricted RAC1 signaling. Besides their role in autophagy and trafficking, we uncovered a previously unknown function of GABARAP proteins as membrane-localized signaling scaffolds.


Authors: Huber, J., Genau, H.M., Baschieri, F., Doetsch, V., Farhan, H., Rogov, V., Behrends, C., Akutsu, M.
CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling.,Genau HM, Huber J, Baschieri F, Akutsu M, Dotsch V, Farhan H, Rogov V, Behrends C Mol Cell. 2015 Feb 11. pii: S1097-2765(14)01018-1. doi:, 10.1016/j.molcel.2014.12.040. PMID:25684205<ref>PMID:25684205</ref>


Description: Crystal structure of GABARAP in complex with KBTBD6 LIR peptide
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Akutsu, M]]
<div class="pdbe-citations 4xc2" style="background-color:#fffaf0;"></div>
[[Category: Doetsch, V]]
 
[[Category: Huber, J]]
==See Also==
[[Category: Baschieri, F]]
*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
[[Category: Farhan, H]]
*[[GABA(A) receptor-associated protein|GABA(A) receptor-associated protein]]
[[Category: Rogov, V]]
== References ==
[[Category: Behrends, C]]
<references/>
[[Category: Genau, H.M]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Akutsu M]]
[[Category: Baschieri F]]
[[Category: Behrends C]]
[[Category: Doetsch V]]
[[Category: Farhan H]]
[[Category: Genau HM]]
[[Category: Huber J]]
[[Category: Rogov VV]]
Retrieved from "https://proteopedia.org/4xc2"