4xc4: Difference between revisions

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'''Unreleased structure'''


The entry 4xc4 is ON HOLD
==Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide==
<StructureSection load='4xc4' size='340' side='right'caption='[[4xc4]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4xc4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3brr 3brr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.499&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc4 OCA], [https://pdbe.org/4xc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc4 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc4 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[https://omim.org/entry/176730 176730].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref>  Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[https://omim.org/entry/125852 125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref>  Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[https://omim.org/entry/606176 606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref>  Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[https://omim.org/entry/613370 613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
== Function ==
[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.


Authors: Bracey, A.W., Magis, A.T., Buschard, K., Osterbye, T., Bailey, K.M., Ostrov, D.A.
==See Also==
 
*[[Insulin 3D Structures|Insulin 3D Structures]]
Description: Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Magis, A.T]]
__TOC__
[[Category: Bracey, A.W]]
</StructureSection>
[[Category: Osterbye, T]]
[[Category: Homo sapiens]]
[[Category: Bailey, K.M]]
[[Category: Large Structures]]
[[Category: Ostrov, D.A]]
[[Category: Bailey KM]]
[[Category: Buschard, K]]
[[Category: Bracey AW]]
[[Category: Buschard K]]
[[Category: Magis AT]]
[[Category: Osterbye T]]
[[Category: Ostrov DA]]
Retrieved from "https://proteopedia.org/4xc4"