3zx7: Difference between revisions

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==Complex of lysenin with phosphocholine==
==Complex of lysenin with phosphocholine==
<StructureSection load='3zx7' size='340' side='right' caption='[[3zx7]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
<StructureSection load='3zx7' size='340' side='right'caption='[[3zx7]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zx7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZX7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zx7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZX7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zxd|3zxd]], [[3zxg|3zxg]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx7 OCA], [https://pdbe.org/3zx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zx7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zx7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zx7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zx7 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TXL_EISFO TXL_EISFO]] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
[https://www.uniprot.org/uniprot/TXL_EISFE TXL_EISFE] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3zx7" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Eisenia fetida]]
[[Category: Eisenia fetida]]
[[Category: Abrusci, P]]
[[Category: Large Structures]]
[[Category: Anderluh, G]]
[[Category: Abrusci P]]
[[Category: Colibus, L De]]
[[Category: Anderluh G]]
[[Category: Gilbert, R J.C]]
[[Category: De Colibus L]]
[[Category: Hodnik, V]]
[[Category: Gilbert RJC]]
[[Category: Leippe, M]]
[[Category: Hodnik V]]
[[Category: Morris, K J]]
[[Category: Leippe M]]
[[Category: Plitzko, J]]
[[Category: Morris KJ]]
[[Category: Siebert, C A]]
[[Category: Plitzko J]]
[[Category: Sonnen, A F.P]]
[[Category: Siebert CA]]
[[Category: Volpi, E]]
[[Category: Sonnen AFP]]
[[Category: Pore forming toxin]]
[[Category: Volpi E]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/3zx7"