4cyg: Difference between revisions
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==The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation== | ==The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation== | ||
<StructureSection load='4cyg' size='340' side='right' caption='[[4cyg]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4cyg' size='340' side='right'caption='[[4cyg]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cyg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYG OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4cyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYG FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=RRV:(2R)-2,4-DIHYDROXY-N-[(3S)-3-HYDROXY-4-PHENYLBUTYL]-3,3-DIMETHYLBUTANAMIDE'>RRV</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=RRV:(2R)-2,4-DIHYDROXY-N-[(3S)-3-HYDROXY-4-PHENYLBUTYL]-3,3-DIMETHYLBUTANAMIDE'>RRV</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyg OCA], [https://pdbe.org/4cyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyg RCSB], [https://www.ebi.ac.uk/pdbsum/4cyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyg ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/VNN1_HUMAN VNN1_HUMAN] Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.<ref>PMID:10567687</ref> <ref>PMID:11491533</ref> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Although part of the coenzyme A pathway, vanin 1 (also known as pantetheinase) sits on the cell surface of many cell types as an ectoenzyme, catalyzing the breakdown of pantetheine to pantothenic acid (vitamin B5) and cysteamine, a strong reducing agent. Vanin 1 was initially discovered as a protein involved in the homing of leukocytes to the thymus. Numerous studies have shown that vanin 1 is involved in inflammation, and more recent studies have shown a key role in metabolic disease. Here, the X-ray crystal structure of human vanin 1 at 2.25 A resolution is presented, which is the first reported structure from the vanin family, as well as a crystal structure of vanin 1 bound to a specific inhibitor. These structures illuminate how vanin 1 can mediate its biological roles by way of both enzymatic activity and protein-protein interactions. Furthermore, it sheds light on how the enzymatic activity is regulated by a novel allosteric mechanism at a domain interface. | |||
The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.,Boersma YL, Newman J, Adams TE, Cowieson N, Krippner G, Bozaoglu K, Peat TS Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3320-9. doi:, 10.1107/S1399004714022767. Epub 2014 Nov 28. PMID:25478849<ref>PMID:25478849</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4cyg" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Adams | [[Category: Large Structures]] | ||
[[Category: Boersma | [[Category: Adams TE]] | ||
[[Category: Bozaoglu | [[Category: Boersma YL]] | ||
[[Category: Cowieson | [[Category: Bozaoglu K]] | ||
[[Category: Krippner | [[Category: Cowieson N]] | ||
[[Category: Lucent | [[Category: Krippner G]] | ||
[[Category: Newman | [[Category: Lucent D]] | ||
[[Category: Peat | [[Category: Newman J]] | ||
[[Category: Sparrow | [[Category: Peat TS]] | ||
[[Category: Sparrow L]] | |||
Latest revision as of 12:17, 20 December 2023
The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation
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