1xee: Difference between revisions
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==Solution structure of the Chemotaxis Inhibitory Protein of Staphylococcus aureus== | ==Solution structure of the Chemotaxis Inhibitory Protein of Staphylococcus aureus== | ||
<StructureSection load='1xee' size='340' side='right' caption='[[1xee | <StructureSection load='1xee' size='340' side='right'caption='[[1xee]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xee]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1xee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xee OCA], [https://pdbe.org/1xee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xee RCSB], [https://www.ebi.ac.uk/pdbsum/1xee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xee ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CHIPS_STAAE CHIPS_STAAE] Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium.<ref>PMID:14993252</ref> <ref>PMID:15153520</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1xee" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
[[Category: Dijkstra | [[Category: Dijkstra K]] | ||
[[Category: Fan | [[Category: Fan H]] | ||
[[Category: Haas | [[Category: Haas PJ]] | ||
[[Category: Kemmink J]] | |||
[[Category: Kemmink | [[Category: Kruijtzer JA]] | ||
[[Category: Liskamp RM]] | |||
[[Category: Kruijtzer | [[Category: Poppelier MJ]] | ||
[[Category: Liskamp | [[Category: Scheek RM]] | ||
[[Category: Poppelier | [[Category: De Haas CJ]] | ||
[[Category: Scheek | [[Category: Van Kessel KP]] | ||
[[Category: | [[Category: Van Strijp JA]] | ||
[[Category: | |||
[[Category: | |||
