3vxv: Difference between revisions
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==Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence== | ==Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence== | ||
<StructureSection load='3vxv' size='340' side='right' caption='[[3vxv]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3vxv' size='340' side='right'caption='[[3vxv]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3vxv]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3vxv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VXV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vxv OCA], [https://pdbe.org/3vxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vxv RCSB], [https://www.ebi.ac.uk/pdbsum/3vxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vxv ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MBD4_MOUSE MBD4_MOUSE] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3vxv" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Methyl CpG binding protein|Methyl CpG binding protein]] | *[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Arita | [[Category: Arita K]] | ||
[[Category: Ariyoshi | [[Category: Ariyoshi M]] | ||
[[Category: Kato | [[Category: Kato T]] | ||
[[Category: Kinoshita | [[Category: Kinoshita M]] | ||
[[Category: Otani | [[Category: Otani J]] | ||
[[Category: Shirakawa | [[Category: Shirakawa M]] | ||
Latest revision as of 10:34, 6 November 2024
Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence
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