2zsi: Difference between revisions

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==Structural basis of gibberellin(GA4)-induced DELLA recognition by the gibberellin receptor==
==Structural basis of gibberellin(GA4)-induced DELLA recognition by the gibberellin receptor==
<StructureSection load='2zsi' size='340' side='right' caption='[[2zsi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2zsi' size='340' side='right'caption='[[2zsi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zsi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZSI FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zsi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZSI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GA4:GIBBERELLIN+A4'>GA4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zsh|2zsh]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GA4:GIBBERELLIN+A4'>GA4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GAI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsi OCA], [https://pdbe.org/2zsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zsi RCSB], [https://www.ebi.ac.uk/pdbsum/2zsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zsi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zsi RCSB], [http://www.ebi.ac.uk/pdbsum/2zsi PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GI1L1_ARATH GI1L1_ARATH]] Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination, stem elongation and flower development. Partially redundant with GID1B and GID1C.<ref>PMID:16709201</ref> <ref>PMID:17194763</ref> <ref>PMID:17521411</ref> [[http://www.uniprot.org/uniprot/GAI_ARATH GAI_ARATH]] Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. No effect of the BOI proteins on its stability. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes. Positively regulates XERICO expression. In contrast to RGA, it is less sensitive to GA. Its activity is probably regulated by other phytohormones such as auxin and ethylene.<ref>PMID:11487693</ref> <ref>PMID:11606551</ref> <ref>PMID:11606552</ref> <ref>PMID:14973286</ref> <ref>PMID:15128937</ref> <ref>PMID:16034591</ref> <ref>PMID:17933900</ref> <ref>PMID:9389651</ref> 
[https://www.uniprot.org/uniprot/GID1A_ARATH GID1A_ARATH] Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination, stem elongation and flower development. Partially redundant with GID1B and GID1C.<ref>PMID:16709201</ref> <ref>PMID:17194763</ref> <ref>PMID:17521411</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2zsi" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Hakoshima, T]]
[[Category: Large Structures]]
[[Category: Hirano, Y]]
[[Category: Hakoshima T]]
[[Category: Murase, K]]
[[Category: Hirano Y]]
[[Category: Sun, T P]]
[[Category: Murase K]]
[[Category: Alpha/beta-hydrolase fold]]
[[Category: Sun TP]]
[[Category: Carboxyesterase family]]
[[Category: Developmental protein]]
[[Category: Gibberellin signaling pathway]]
[[Category: Hormone receptor]]
[[Category: Hydrolase]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Plant hormone receptor]]
[[Category: Receptor]]
[[Category: Repressor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
Retrieved from "https://proteopedia.org/2zsi"