4bvc: Difference between revisions
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==Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.== | ==Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.== | ||
<StructureSection load='4bvc' size='340' side='right' caption='[[4bvc]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='4bvc' size='340' side='right'caption='[[4bvc]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BVC FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bvc OCA], [https://pdbe.org/4bvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bvc RCSB], [https://www.ebi.ac.uk/pdbsum/4bvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bvc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Althage | [[Category: Homo sapiens]] | ||
[[Category: Andersson | [[Category: Large Structures]] | ||
[[Category: Antonsson | [[Category: Althage M]] | ||
[[Category: Blaho | [[Category: Andersson GMK]] | ||
[[Category: Bodin | [[Category: Antonsson T]] | ||
[[Category: Bostrom | [[Category: Blaho S]] | ||
[[Category: Chen | [[Category: Bodin C]] | ||
[[Category: Dahlen | [[Category: Bostrom J]] | ||
[[Category: Eriksson | [[Category: Chen Y]] | ||
[[Category: Evertsson | [[Category: Dahlen A]] | ||
[[Category: Fex | [[Category: Eriksson PO]] | ||
[[Category: Fjellstrom | [[Category: Evertsson E]] | ||
[[Category: Gustafsson | [[Category: Fex T]] | ||
[[Category: Hallberg | [[Category: Fjellstrom O]] | ||
[[Category: Hicks | [[Category: Gustafsson D]] | ||
[[Category: Jarkvist | [[Category: Hallberg C]] | ||
[[Category: Johansson | [[Category: Hicks R]] | ||
[[Category: Kalies | [[Category: Jarkvist E]] | ||
[[Category: Kang | [[Category: Johansson C]] | ||
[[Category: Kalies I]] | |||
[[Category: Kartberg | [[Category: Kang D]] | ||
[[Category: Knecht | [[Category: Kartberg F]] | ||
[[Category: Legnehed | [[Category: Knecht W]] | ||
[[Category: Lindqvist | [[Category: Legnehed A]] | ||
[[Category: Martinsson | [[Category: Lindqvist AM]] | ||
[[Category: Moberg | [[Category: Martinsson SA]] | ||
[[Category: Petersson | [[Category: Moberg A]] | ||
[[Category: Ridderstrom | [[Category: Petersson AU]] | ||
[[Category: Sandmark | [[Category: Ridderstrom M]] | ||
[[Category: Thelin | [[Category: Sandmark J]] | ||
[[Category: Tigerstrom | [[Category: Svalstedt Karlsson B]] | ||
[[Category: Vinblad | [[Category: Thelin A]] | ||
[[Category: Xu | [[Category: Tigerstrom A]] | ||
[[Category: Vinblad J]] | |||
[[Category: Xu B]] | |||
Latest revision as of 11:58, 20 December 2023
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Large Structures
- Althage M
- Andersson GMK
- Antonsson T
- Blaho S
- Bodin C
- Bostrom J
- Chen Y
- Dahlen A
- Eriksson PO
- Evertsson E
- Fex T
- Fjellstrom O
- Gustafsson D
- Hallberg C
- Hicks R
- Jarkvist E
- Johansson C
- Kalies I
- Kang D
- Kartberg F
- Knecht W
- Legnehed A
- Lindqvist AM
- Martinsson SA
- Moberg A
- Petersson AU
- Ridderstrom M
- Sandmark J
- Svalstedt Karlsson B
- Thelin A
- Tigerstrom A
- Vinblad J
- Xu B
