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==Crystal structure of SULT 2A1 LLGG mutant with PAPS==
==Crystal structure of SULT 2A1 LLGG mutant with PAPS==
<StructureSection load='4ifb' size='340' side='right' caption='[[4ifb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4ifb' size='340' side='right'caption='[[4ifb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ifb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IFB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ifb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IFB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PPS:3-PHOSPHATE-ADENOSINE-5-PHOSPHATE+SULFATE'>PPS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT2A1, HST, STD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PPS:3-PHOSPHATE-ADENOSINE-5-PHOSPHATE+SULFATE'>PPS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bile-salt_sulfotransferase Bile-salt sulfotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.14 2.8.2.14] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ifb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifb OCA], [https://pdbe.org/4ifb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ifb RCSB], [https://www.ebi.ac.uk/pdbsum/4ifb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ifb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ifb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ifb RCSB], [http://www.ebi.ac.uk/pdbsum/4ifb PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ST2A1_HUMAN ST2A1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.  
[https://www.uniprot.org/uniprot/ST2A1_HUMAN ST2A1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.


==See Also==
==See Also==
*[[Sulfotransferase|Sulfotransferase]]
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bile-salt sulfotransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C]]
[[Category: Large Structures]]
[[Category: Bhosle, R]]
[[Category: Almo SC]]
[[Category: Cook, I]]
[[Category: Bhosle R]]
[[Category: Falany, C N]]
[[Category: Cook I]]
[[Category: Kim, J]]
[[Category: Falany CN]]
[[Category: Leyh, T S]]
[[Category: Kim J]]
[[Category: Toro, R]]
[[Category: Leyh TS]]
[[Category: Wang, T]]
[[Category: Toro R]]
[[Category: Sulfotransferase]]
[[Category: Wang T]]
[[Category: Transferase]]

Latest revision as of 15:21, 20 September 2023

Crystal structure of SULT 2A1 LLGG mutant with PAPS

4ifb, resolution 2.30Å

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