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==Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex==
==Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex==
<StructureSection load='4j57' size='340' side='right' caption='[[4j57]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4j57' size='340' side='right'caption='[[4j57]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4j57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J57 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4j57]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J57 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trxr2, PFI1170c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7]), PF14_0545 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j57 OCA], [https://pdbe.org/4j57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j57 RCSB], [https://www.ebi.ac.uk/pdbsum/4j57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j57 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j57 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j57 RCSB], [http://www.ebi.ac.uk/pdbsum/4j57 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THIO_PLAF7 THIO_PLAF7]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).  
[https://www.uniprot.org/uniprot/TRXR_PLAF7 TRXR_PLAF7] Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins (PubMed:11013257, PubMed:16910770, PubMed:23845423, PubMed:9368022). Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO (PubMed:11013257). Has no catalytic activity towards oxidized glutathione (GSSG) (PubMed:11013257).<ref>PMID:11013257</ref> <ref>PMID:16910770</ref> <ref>PMID:23845423</ref> <ref>PMID:9368022</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4j57" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Thioredoxin|Thioredoxin]]
*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
*[[Thioredoxin Reductase|Thioredoxin Reductase]]
*[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plasmodium falciparum 3d7]]
[[Category: Large Structures]]
[[Category: Thioredoxin-disulfide reductase]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Becker, K]]
[[Category: Becker K]]
[[Category: Fritz-Wolf, K]]
[[Category: Fritz-Wolf K]]
[[Category: Iozef, R]]
[[Category: Iozef R]]
[[Category: Jortzik, E]]
[[Category: Jortzik E]]
[[Category: Preuss, J]]
[[Category: Preuss J]]
[[Category: Rahlfs, S]]
[[Category: Rahlfs S]]
[[Category: Stumpf, M]]
[[Category: Stumpf M]]
[[Category: Disulfide reductase]]
[[Category: Fad binding]]
[[Category: Nadph binding]]
[[Category: Oxidoreductase]]
[[Category: Protein-protein complex]]
[[Category: Thioredoxin binding]]
[[Category: Thioredoxin fold]]
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