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==Crystal structure of the DnaK C-terminus with the inhibitor PET-16==
==Crystal structure of the DnaK C-terminus with the inhibitor PET-16==
<StructureSection load='4r5g' size='340' side='right' caption='[[4r5g]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
<StructureSection load='4r5g' size='340' side='right'caption='[[4r5g]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4r5g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R5G FirstGlance]. <br>
<table><tr><td colspan='2'>[[4r5g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R5G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3JE:TRIPHENYL(PHENYLETHYNYL)PHOSPHONIUM'>3JE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4501&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r5g RCSB], [http://www.ebi.ac.uk/pdbsum/4r5g PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3JE:TRIPHENYL(PHENYLETHYNYL)PHOSPHONIUM'>3JE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5g OCA], [https://pdbe.org/4r5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r5g RCSB], [https://www.ebi.ac.uk/pdbsum/4r5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]  
[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4r5g" style="background-color:#fffaf0;"></div>
==See Also==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: George, D L]]
[[Category: Escherichia coli K-12]]
[[Category: Leu, J I]]
[[Category: Large Structures]]
[[Category: Marmorstein, R]]
[[Category: George DL]]
[[Category: Murphy, M E]]
[[Category: Leu JI]]
[[Category: Zhang, P]]
[[Category: Marmorstein R]]
[[Category: Beta sheet]]
[[Category: Murphy ME]]
[[Category: Chaperone]]
[[Category: Zhang P]]
[[Category: Chaperone-chaperone inhibitor complex]]
[[Category: Helical bundle]]
[[Category: Hsp70/dnak inhibitor]]
[[Category: Membrane]]
Retrieved from "https://proteopedia.org/4r5g"