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==Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1297==
==Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1297==
<StructureSection load='4h38' size='340' side='right' caption='[[4h38]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4h38' size='340' side='right'caption='[[4h38]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h38]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H38 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h38]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H38 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0YX:(5-BROMO-2-{[3-(OCTYLOXY)BENZYL]OXY}PHENYL)PHOSPHONIC+ACID'>0YX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h2j|4h2j]], [[4h2m|4h2m]], [[4h2o|4h2o]], [[4h3a|4h3a]], [[4h3c|4h3c]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0YX:(5-BROMO-2-{[3-(OCTYLOXY)BENZYL]OXY}PHENYL)PHOSPHONIC+ACID'>0YX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">uppS, ispU, rth, yaeS, b0174, JW0169 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h38 OCA], [https://pdbe.org/4h38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h38 RCSB], [https://www.ebi.ac.uk/pdbsum/4h38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h38 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Di-trans,poly-cis-decaprenylcistransferase Di-trans,poly-cis-decaprenylcistransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.31 2.5.1.31] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h38 RCSB], [http://www.ebi.ac.uk/pdbsum/4h38 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI]] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>
[https://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4h38" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Di-trans,poly-cis-decaprenylcistransferase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Oldfield, E]]
[[Category: Large Structures]]
[[Category: Zhu, W]]
[[Category: Oldfield E]]
[[Category: Alpha-helix]]
[[Category: Zhu W]]
[[Category: Cell wall biosynthesis]]
[[Category: Farnesyl diphosphate binding]]
[[Category: Isopentenyl diphosphate binding]]
[[Category: Prenyl transferase]]
[[Category: Prenyl transferase inhibitor complex]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4h38"