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==Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with p38alpha NREb==
==Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with p38alpha NREb==
<StructureSection load='3q0r' size='340' side='right' caption='[[3q0r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3q0r' size='340' side='right'caption='[[3q0r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q0R FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0R FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q0l|3q0l]], [[3q0m|3q0m]], [[3q0n|3q0n]], [[3q0o|3q0o]], [[3q0p|3q0p]], [[3q0q|3q0q]], [[3q0s|3q0s]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PUM2, KIAA0235, PUMH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0r OCA], [https://pdbe.org/3q0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0r RCSB], [https://www.ebi.ac.uk/pdbsum/3q0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q0r RCSB], [http://www.ebi.ac.uk/pdbsum/3q0r PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PUM2_HUMAN PUM2_HUMAN]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.  
[https://www.uniprot.org/uniprot/PUM2_HUMAN PUM2_HUMAN] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3q0r" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hall, T M.T]]
[[Category: Large Structures]]
[[Category: Lu, G]]
[[Category: Hall TMT]]
[[Category: Gene regulation]]
[[Category: Lu G]]
[[Category: Puf]]
[[Category: Pumilio-homolgy domain]]
[[Category: Rna binding]]
[[Category: Rna binding protein-rna complex]]
Retrieved from "https://proteopedia.org/3q0r"